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Updated version of Alan Guth's talk -- now with slides! -- can be found here, https://www.youtube.com/watch?v=AmamlnbDX9I fqxi.org The past century in physics seems to lead in a surprising direction: away from physics as a description of objects and their interactions, and towards physics as a description of the evolution of information. Is this the correct way to think about physics and the physical world? What is information? What does the term "information" even mean? What role does information play in quantum gravity, cosmology, thermodynamics, life and consciousness, and what links does it provide between these areas? FQXi's international, interdisciplinary conference on the Physics of Information brought together leading researchers to discuss the significance, meaning, and uses of information in physics.